Glutamine


Glutamine

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Somewhere along the line, Mother Nature made a few decisions regarding which amino acids would be used to fuel the body's life support systems. Not wanting to risk the biological equivalent of a blackout, she chose not to use essential amino acids since the supply could potentially be interrupted by a poor diet. Instead, she selected nonessential amino acids, because as long as the body has at least one scrap of muscle somewhere, a supply of amino acids exists that can be used to support vital functions.

Glutamine is one such nonessential amino acid. It fuels some of the body's major systems, like the brain, intestines, kidneys, lungs and immune system,. The body will literally digest its own muscle tissue to get glutamine if not enough is ingested.

If you're like most people - or most bodybuilders, at least - the thought of cannibalizing muscle tissue simply to get glutamine makes about as much sense as buying a Bently just to get a set of tires. But hang on: If you think you should supplement with glutamine just to prevent your hard-earned muscle from being little more than an amino donor for your organs, read on.

  • Increases Muscle Protein Synthesis - Glutamine has been positively linked to increased protein synthesis by establishing a positive intramuscular glutamine pool. This spares the muscle tissue from being cannibalized to provide glutamine for other cells in the body, allowing the muscle tissue to use glutamine to synthesize new protein tissue.

  • Increases Cell Volume - Cellular hydration state has a major influence on cell function. Glutamine was shown to increase cell volume. Interestingly, insulin and glutamine together seem to work even better at volumizing the cell. Cell swelling has also shown to promote glycogen synthesis in liver and muscle tissue. Glutamine had a stimulatory effect on glycogen accumulation in human skeletal muscle. This suggests that the availability of glutamine after exercise promotes muscle glycogen accumulation by mechanisms possibly including diversion of glutamine carbon skeleton to glycogen.

  • Maintains Acid-Base Balance - A small glutamine load of 2 grams increased plasma alkaline reserves, which may contribute to acid-base balance. Glutamine may be beneficial in regulating acid-base balance since it increases plasma bicarbonate concentration. This could be beneficial to athletes who might need help buffering lactic acid during multiple sets of high-intensity exercise.

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